The Phosphorus Turnover of Carcinoma of the Human Stomach as Measured with Radioactive Phosphorus.

نویسندگان

  • J Schulman
  • M Falkenheim
  • S J Gray
چکیده

The phosphorus turnover of tumors has been widely studied in animals and has been found to be higher than in normal tissues. Several blood dyscrasias have also been investigated extensively (1-3). The high uptake of radiophosphorus by leukemic cells and by red cells in polycythemia vera has been applied to the treatment of these diseases (4, 5). Low-Beer and collaborators have observed an increased uptake of radiophosphorus by human breast carcinomas as measured through the skin in vivo (6); but they have derived no information about turnover. Since no studies have been made of the turnover of phosphorus in naturally occurring human cancers, we thought it of interest to investigate the phosphorus turnover of carcinoma of the human stomach, one of the most common of human malignancies. Because phosphorus takes part in so many reactions of the body, it also seemed of interest to determine whether any change in phosphorus metabolism was related to any particular group of compounds. Therefore, the turnover of the acid soluble, lipid, and protein phosphorus fractions was determined independently. The possible existence of quantitative differences in the phosphorus content of normal tissue and of tumor tissue was also investigated.

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 28 1  شماره 

صفحات  -

تاریخ انتشار 1949